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In Vitro Developmental Acceleration of Hippocampal Neurons on Nanostructures of Self‐Assembled Silica Beads in Filopodium‐Size Ranges
Author(s) -
Kang Kyungtae,
Choi SungEun,
Jang Hee Su,
Cho Woo Kyung,
Nam Yoonkey,
Choi Insung S.,
Lee Jin Seok
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201106271
Subject(s) - hippocampal formation , neurite , nanostructure , nanotechnology , neuroscience , bar (unit) , acceleration , computer science , biology , materials science , in vitro , chemistry , biophysics , physics , biochemistry , meteorology , classical mechanics
Something to sprout about : The developmental acceleration of hippocampal neurons occurred on well‐packed structures of silica beads with diameters over 200 nm (see picture; scale bar: 5 μm, inset scale bar: 1 μm). The neurons sensed the size differences of the nanostructures and altered their behaviors, thus implying that nanotopographical stimuli are one of the important features for guiding neurites during neural developments in vivo.