Premium
Iridium‐Catalyzed Chemoselective and Enantioselective Hydrogenation of (1‐Chloro‐1‐Alkenyl) Boronic Esters
Author(s) -
Gazić Smilović Ivana,
CasasArcé Eva,
Roseblade Stephen J.,
Nettekoven Ulrike,
ZanottiGerosa Antonio,
Kovačevič Miroslav,
Časar Zdenko
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201106262
Subject(s) - iridium , enantioselective synthesis , chlorine , substituent , chemistry , catalysis , organic chemistry , combinatorial chemistry
Persistent chlorine : Hydrogenation of borolane‐substituted vinylic chlorides catalyzed by IrP N complexes greatly preserved the chlorine substituent on the hydrogenated product, with only 3–19 % of dechlorinated byproducts present after hydrogenation. The α‐chloro boronic ester products are ideal precursors for proteasome‐inhibitor‐type anti‐cancer drugs, a fact which demonstrates the utility of this hydrogenation method.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom