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Creation of a Lipase Highly Selective for trans Fatty Acids by Protein Engineering
Author(s) -
Brundiek Henrike B.,
Evitt Andrew S.,
Kourist Robert,
Bornscheuer Uwe T.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201106126
Subject(s) - chemoselectivity , lipase , chemistry , protein engineering , biochemistry , enzyme , organic chemistry , food science , catalysis
Sorting out : Protein engineering of lipase CAL‐A led to the discovery of mutants with excellent chemoselectivity for the removal of trans and saturated fatty acids from partially hydrogenated vegetable oil. These fatty acids, identified as a major risk factor for human health, can now be removed by enzyme catalysis.