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Total Synthesis of Tulearin C
Author(s) -
Lehr Konrad,
Mariz Ronaldo,
Leseurre Lucie,
Gabor Barbara,
Fürstner Alois
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201106117
Subject(s) - brother , metathesis , alkene , alkyne , computer science , chemistry , organic chemistry , sociology , catalysis , polymerization , anthropology , polymer
With the help of the smaller brother : Although alkyne metathesis will always be the little brother of alkene metathesis, it allows problems to be solved that are currently beyond reach of the more famous sibling. This notion is exemplified by the tulearin macrolides, which could only be selectively forged by ring‐closing alkyne metathesis (RCAM)/ trans reduction using the latest generation of alkyne metathesis catalysts.