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Chlorostyrenes in Iron‐Catalyzed Biaryl Coupling Reactions
Author(s) -
Gülak Samet,
Jacobi von Wangelin Axel
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201106110
Subject(s) - aryl , catalysis , reagent , substituent , combinatorial chemistry , chemistry , cleavage (geology) , bond cleavage , conjugated system , organic chemistry , materials science , alkyl , polymer , fracture (geology) , composite material
An effective protocol for iron‐catalyzed biaryl syntheses by coupling chlorostyrenes with aryl Grignard reagents requires only mild reaction conditions and tolerates various functional groups. The underlying activation of deactivated aryl chlorides proceeds through a rate‐determining coordination of the catalyst to the vinyl substituent and subsequent haptotropic migration along the conjugated π system to the site of CCl bond cleavage.