Premium
Photocontrollable Dynamic Micropatterning of Non‐adherent Mammalian Cells Using a Photocleavable Poly(ethylene glycol) Lipid
Author(s) -
Yamaguchi Satoshi,
Yamahira Shinya,
Kikuchi Kyoko,
Sumaru Kimio,
Kanamori Toshiyuki,
Nagamune Teruyuki
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201106106
Subject(s) - ethylene glycol , peg ratio , micropatterning , substrate (aquarium) , linker , chemistry , biophysics , nanotechnology , combinatorial chemistry , materials science , computer science , biology , organic chemistry , operating system , finance , economics , ecology
Cells in the spotlight : A substrate was coated with a poly(ethylene glycol) (PEG) segment bound to a lipid through a linker that was cleaved by UV irradiation to leave a PEG‐coated area. Irradiation of an arbitrary pattern easily and rapidly yielded a high‐contrast cell pattern. Only the targeted cells on the cell pattern were selectively detached without cell damage on a microfluidic device (see picture).