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A Structural Basis for the Antibiotic Resistance Conferred by an A1408G Mutation in 16S rRNA and for the Antiprotozoal Activity of Aminoglycosides
Author(s) -
Kondo Jiro
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201106084
Subject(s) - aminoglycoside , antiprotozoal , ribosomal rna , mutation , genetics , biology , snapshot (computer storage) , antibiotics , computational biology , antibiotic resistance , microbiology and biotechnology , computer science , gene , database , in vitro
Resistance explained : The crystal structures of the ribosomal decoding A site with an A1408G antibiotic‐resistance mutation were solved in the presence and absence of the aminoglycoside geneticin (see structure, geneticin carbon framework in yellow). These structures show how bacteria acquire high‐level resistance against aminoglycosides by the mutation.