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Cooperative Hierarchical Self‐Assembly of Peptide Dendrimers and Linear Polypeptides into Nanoarchitectures Mimicking Viral Capsids
Author(s) -
Xu Xianghui,
Yuan Hui,
Chang Jing,
He Bin,
Gu Zhongwei
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201106080
Subject(s) - capsid , dendrimer , peptide , transfection , residue (chemistry) , lysine , biophysics , nanoparticle , chemistry , amino acid , virus , nanotechnology , virology , materials science , biochemistry , biology , gene
Peptidesomes are nanoparticles that are built by a two‐step self‐assembly of globular peptide dendrimers with lysine endgroups (red spheres in picture) and poly( L ‐leucine) carrying one glutamic acid residue (blue lines with red dot). These viral‐capsid‐mimicking nanoarchitectures exhibit high gene transfection efficacy and thus are promising nonviral vectors for biomedical applications.