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Engineered Bacterially Expressed Polypeptides: Assembly into Polymer Particles with Tailored Degradation Profiles
Author(s) -
Chang Denison H. C.,
Johnston Angus P. R.,
Wark Kim L.,
Breheney Kerry,
Caruso Frank
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201106033
Subject(s) - degradation (telecommunications) , exploit , genetic code , sequence (biology) , amino acid , computer science , polymer , computational biology , scheme (mathematics) , chemistry , biosynthesis , process (computing) , combinatorial chemistry , gene , biochemistry , biology , programming language , mathematics , organic chemistry , telecommunications , computer security , mathematical analysis
In nature , the sequence of amino acids in a protein is determined by the genetic code. Biosynthesis of polypeptides by bacteria can be used to exploit this natural process to afford exact control over properties such as molecular weight, chemical functionality, and structure. It is demonstrated how control over the positioning of functional groups can be used to tune the degradation of assembled polypeptide particles (see scheme).