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Back Cover: Development of Highly Cytotoxic and Actin‐Depolymerizing Biotin Derivatives of Aplyronine A (Angew. Chem. Int. Ed. 42/2011)
Author(s) -
Kita Masaki,
Hirayama Yuichiro,
Sugiyama Miyuki,
Kigoshi Hideo
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201106017
Subject(s) - actin , cytotoxicity , int , chemistry , cytotoxic t cell , ethylene glycol , biotin , aplysia , lysis , biochemistry , derivative (finance) , biology , in vitro , organic chemistry , computer science , operating system , evolutionary biology , economics , financial economics
Aplyronine A is an antitumor macrolide from the sea hare Aplysia kurodai. In their Communication on page 9871 ff., H. Kigoshi and co‐workers report the synthesis of a poly(ethylene glycol) (PEG)‐linked derivative of aplyronine A, which exhibits potent cytotoxicity and can cause actin disassembly in tumor cells. Actin‐related proteins as well as actin were specifically purified from cell lysate by using this probe.