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Cross‐Coupling of Nonactivated Alkyl Halides with Alkynyl Grignard Reagents: A Nickel Pincer Complex as the Catalyst
Author(s) -
Vechorkin Oleg,
Godinat Aurélien,
Scopelliti Rosario,
Hu Xile
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201105964
Subject(s) - pincer movement , nickel , tetrahydrofuran , catalysis , ether , halide , chemistry , alkyl , substrate (aquarium) , coupling (piping) , combinatorial chemistry , medicinal chemistry , organic chemistry , polymer chemistry , materials science , solvent , biology , ecology , metallurgy
In a pinch : The nickel pincer complex 1 catalyzes the cross‐coupling of the title compounds with remarkable substrate scope and functional group tolerance. A nickel/alkynyl species was isolated and shown to be catalytically competent. THF=tetrahydrofuran, O‐TMEDA=bis[2‐( N , N ‐dimethylaminoethyl)] ether.