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Stable Fluorophosphines: Predicted and Realized Ligands for Catalysis
Author(s) -
Fey Natalie,
Garland Michael,
Hopewell Jonathan P.,
McMullin Claire L.,
Mastroianni Sergio,
Orpen A. Guy,
Pringle Paul G.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201105954
Subject(s) - hydroformylation , ligand (biochemistry) , disproportionation , catalysis , hydrocyanation , chemistry , organic chemistry , rhodium , biochemistry , receptor
Ligand maps lead to treasure! The activity of complexes of fluorophosphines (R 2 PF) in catalytic hydroformylation and hydrocyanation is predicted from a ligand map. However, the instability of R 2 PF to disproportionation is well‐documented. Examples of R 2 PF ligands (see scheme) are described that are stabilized to such an extent that they can be used in catalysis and are shown to be highly effective.