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Immunosuppressive Small Molecule Discovered by Structure‐Based Virtual Screening for Inhibitors of Protein–Protein Interactions
Author(s) -
Geppert Tim,
Bauer Stefanie,
Hiss Jan A.,
Conrad Elea,
Reutlinger Michael,
Schneider Petra,
Weisel Martin,
Pfeiffer Bernhard,
Altmann KarlHeinz,
Waibler Zoe,
Schneider Gisbert
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201105901
Subject(s) - virtual screening , in vitro , interferon , small molecule , protein–protein interaction , chemistry , computational biology , receptor , microbiology and biotechnology , biophysics , biology , drug discovery , biochemistry , immunology
Interfering with interferon : A low‐molecular‐weight inhibitor has been discovered that blocks the interaction between interferon‐α (IFN‐α) and its receptor (see picture for a model of the interfaces). The resulting lead compound significantly reduces IFN‐α production in vitro. NMR and SPR experiments confirm the direct interaction of the inhibitor with IFN‐α.