Taming the Friedel–Crafts Reaction: Organocatalytic Approach to Optically Active 2,3‐Dihydrobenzofurans | Zendy

Albrecht Łukasz | Zendy; Ransborg Lars Krogager | Zendy; Lauridsen Vibeke | Zendy; Overgaard Mette | Zendy; Zweifel Theo | Zendy; Jørgensen Karl Anker | Zendy

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Taming the Friedel–Crafts Reaction: Organocatalytic Approach to Optically Active 2,3‐Dihydrobenzofurans

Author(s) -

Albrecht Łukasz,

Ransborg Lars Krogager,

Lauridsen Vibeke,

Overgaard Mette,

Zweifel Theo,

Jørgensen Karl Anker

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201105819

Subject(s) - optically active , stereocenter , friedel–crafts reaction , reactivity (psychology) , trimethylsilyl , chemistry , combinatorial chemistry , simple (philosophy) , organic chemistry , catalysis , enantioselective synthesis , pathology , medicine , philosophy , alternative medicine , epistemology

Fine‐tuning : Three types of optically active trans ‐2,3‐disubstituted‐2,3‐dihydrobenzofurans having three contiguous stereogenic centers can be efficiently accessed by one‐pot reaction cascades (see scheme; TMS=trimethylsilyl). High substitution diversity of the final products can be achieved from the same common precursors by fine‐tuning of their reactivity through simple structural modifications.

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