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Enantioselective Stetter Reactions of Enals and Modified Chalcones Catalyzed by N‐Heterocyclic Carbenes
Author(s) -
Fang Xinqiang,
Chen Xingkuan,
Lv Hui,
Chi Yonggui Robin
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201105812
Subject(s) - enantioselective synthesis , reactivity (psychology) , chemistry , catalysis , organocatalysis , combinatorial chemistry , organic chemistry , stereochemistry , medicine , alternative medicine , pathology
New trick for an old cat. : Triazolium‐based N‐heterocyclic carbenes (NHCs) catalyze the selective generation of acyl anion equivalents for the title reaction. The stereoelectronic properties of the enal‐derived Breslow intermediates and the unique reactivity of the modified chalcones are crucial for the Stetter reactions to occur. EWG=electron‐ withdrawing group.