Chiral Iridium Catalysts Bearing Spiro Pyridine‐Aminophosphine Ligands Enable Highly Efficient Asymmetric Hydrogenation of β ‐ Aryl β‐Ketoesters | Zendy

Xie JianHua | Zendy; Liu XiaoYan | Zendy; Yang XiaoHui | Zendy; Xie JianBo | Zendy; Wang LiXin | Zendy; Zhou QiLin | Zendy

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Chiral Iridium Catalysts Bearing Spiro Pyridine‐Aminophosphine Ligands Enable Highly Efficient Asymmetric Hydrogenation of β ‐ Aryl β‐Ketoesters

Author(s) -

Xie JianHua,

Liu XiaoYan,

Yang XiaoHui,

Xie JianBo,

Wang LiXin,

Zhou QiLin

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201105780

Subject(s) - iridium , catalysis , pyridine , cyclooctadiene , yield (engineering) , asymmetric hydrogenation , chemistry , aryl , ligand (biochemistry) , bearing (navigation) , medicinal chemistry , combinatorial chemistry , organic chemistry , enantioselective synthesis , materials science , computer science , receptor , metallurgy , biochemistry , alkyl , artificial intelligence

Tons of TONs : Chiral iridium catalysts bearing ligand 1 are highly efficient for the asymmetric hydrogenation of β‐substituted β‐ketoesters. The product β‐hydroxyesters are delivered in high yield with excellent enantioselectivities and high turnover numbers (TONs). cod= 1,5‐cyclooctadiene.

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