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Chiral Iridium Catalysts Bearing Spiro Pyridine‐Aminophosphine Ligands Enable Highly Efficient Asymmetric Hydrogenation of β ‐ Aryl β‐Ketoesters
Author(s) -
Xie JianHua,
Liu XiaoYan,
Yang XiaoHui,
Xie JianBo,
Wang LiXin,
Zhou QiLin
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201105780
Subject(s) - iridium , catalysis , pyridine , cyclooctadiene , yield (engineering) , asymmetric hydrogenation , chemistry , aryl , ligand (biochemistry) , bearing (navigation) , medicinal chemistry , combinatorial chemistry , organic chemistry , enantioselective synthesis , materials science , computer science , receptor , metallurgy , biochemistry , alkyl , artificial intelligence
Tons of TONs : Chiral iridium catalysts bearing ligand 1 are highly efficient for the asymmetric hydrogenation of β‐substituted β‐ketoesters. The product β‐hydroxyesters are delivered in high yield with excellent enantioselectivities and high turnover numbers (TONs). cod= 1,5‐cyclooctadiene.