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Diisobutylaluminum Hydride Mediated Regioselective O Desilylations: Access to Multisubstituted Cyclodextrins
Author(s) -
Ghosh Ramprasad,
Zhang Ping,
Wang Aixia,
Ling ChangChun
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201105737
Subject(s) - regioselectivity , reagent , hydride , combinatorial chemistry , chemistry , medicinal chemistry , organic chemistry , catalysis , hydrogen
A face off : Diisobutylaluminum hydride (DIBAL‐H) has been found to be an effective O‐desilylating reagent at the primary face of cyclodextrins. This methodology shows high chemo‐ and regioselectivity and provides an effective route to orthogonally protected, multisubstituted cyclodextrin derivatives.