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Molecular Details of the Recognition of Blood Group Antigens by a Human Norovirus as Determined by STD NMR Spectroscopy
Author(s) -
Fiege Brigitte,
Rademacher Christoph,
Cartmell Jonathan,
Kitov Pavel I.,
Parra Francisco,
Peters Thomas
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201105719
Subject(s) - norovirus , epitope , antigen , spectroscopy , nuclear magnetic resonance spectroscopy , computational biology , human blood , tracing , blood group antigens , chemistry , virology , biochemistry , biology , genetics , stereochemistry , computer science , virus , physics , physiology , quantum mechanics , operating system
Tracing the infection : The binding of human norovirus particles to blood group antigens was investigated using NMR spectroscopy. Binding epitopes were determined at atomic resolution, information on the binding specificity was obtained, and the bioactive conformation of various sugars was revealed. This provides valuable information for the design of entry inhibitors against this important class of human pathogenic viruses.