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Catalytic Enantioselective 1,2‐Diboration of 1,3‐Dienes: Versatile Reagents for Stereoselective Allylation
Author(s) -
Kliman Laura T.,
Mlynarski Scott N.,
Ferris Grace E.,
Morken James P.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201105716
Subject(s) - enantioselective synthesis , chemistry , catalysis , reagent , stereoselectivity , boron , combinatorial chemistry , alcohol , organic chemistry
More with boron : The development of catalytic enantioselective 1,2‐diboration of 1,3‐dienes enables a new strategy for enantioselective carbonyl allylation reactions (see scheme). These reactions occur with outstanding levels of stereoselection and can be applied to both monosubstituted and 1,1‐disubstituted dienes. The carbonyl allylation reactions provide enantiomerically enriched functionalized homoallylic alcohol products.