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Supramolecular Host–Guest Interaction for Labeling and Detection of Cellular Biomarkers
Author(s) -
Agasti Sarit S.,
Liong Monty,
Tassa Carlos,
Chung Hyun Jung,
Shaw Stanley Y.,
Lee Hakho,
Weissleder Ralph
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201105670
Subject(s) - supramolecular chemistry , bioorthogonal chemistry , computational biology , profiling (computer programming) , adamantane , host (biology) , computer science , chemistry , nanotechnology , combinatorial chemistry , biology , molecule , click chemistry , genetics , materials science , organic chemistry , operating system
Be my guest : A supramolecular host–guest interaction is utilized for highly efficient bioorthogonal labeling of cellular targets. Antibodies labeled with a cyclodextrin host molecule bind to adamantane‐labeled magnetofluorescent nanoparticles (see picture) and provide an amplifiable strategy for biomarker detection that can be adapted to different diagnostic techniques such as molecular profiling or magnetic cell sorting.