Pd II ‐Catalyzed CH Olefination of  N ‐(2‐Pyridyl)sulfonyl Anilines and Arylalkylamines | Zendy

GarcíaRubia Alfonso | Zendy; Urones Beatriz | Zendy; Gómez Arrayás Ramón | Zendy; Carretero Juan C. | Zendy

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Pd II ‐Catalyzed CH Olefination of N ‐(2‐Pyridyl)sulfonyl Anilines and Arylalkylamines

Author(s) -

GarcíaRubia Alfonso,

Urones Beatriz,

Gómez Arrayás Ramón,

Carretero Juan C.

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201105611

Subject(s) - sulfonyl , aniline , chemistry , aryl , benzylamine , catalysis , alkyl , medicinal chemistry , organic chemistry

Flexible friend : The N ‐(2‐pyridyl)sulfonyl group acts as a removable directing group in the Pd II ‐catalyzed aryl CH ortho alkenylation of N ‐alkyl aniline, benzylamine, and phenethylamine derivatives with electron‐poor alkenes. The products were obtained in high yields (70–90 %) and with complete regiocontrol. The mild reductive N ‐sulfonyl removal enables the construction of a variety of nitrogen heterocycles. EWG=electron‐withdrawing group.

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