Multivalent Glycocluster Design through Directed Evolution | Zendy

MacPherson Iain S. | Zendy; Temme J. Sebastian | Zendy; Habeshian Sevan | Zendy; Felczak Krzysztof | Zendy; Pankiewicz Krzysztof | Zendy; Hedstrom Lizbeth | Zendy; Krauss Isaac J. | Zendy

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Multivalent Glycocluster Design through Directed Evolution

Author(s) -

MacPherson Iain S.,

Temme J. Sebastian,

Habeshian Sevan,

Felczak Krzysztof,

Pankiewicz Krzysztof,

Hedstrom Lizbeth,

Krauss Isaac J.

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201105555

Subject(s) - glycan , avidity , chemistry , dendrimer , ligand (biochemistry) , selectin , glycome , cell adhesion , computational biology , biochemistry , receptor , biophysics , glycoprotein , microbiology and biotechnology , adhesion , cell , biology , antigen , genetics , organic chemistry

Selection with modified aptamers : A method is described for design of glycocluster ligands by directed evolution. Glycan azides are attached to a library of alkyne‐containing DNA sequences. DNA sequences which cluster the glycans best for multivalent binding to the target are selected and amplified. This method has been applied to the development of high‐mannose clusters which bind HIV‐neutralizing antibody 2G12.

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