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The Dynamic Structure of Filamentous Tau
Author(s) -
Bibow Stefan,
Mukrasch Marco D.,
Chinnathambi Subashchandrabose,
Biernat Jacek,
Griesinger Christian,
Mandelkow Eckhard,
Zweckstetter Markus
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201105493
Subject(s) - computational biology , chemistry , biology
Getting inside a fuzzy coat : The dynamic structure of the “fuzzy coat”, N‐ and C‐terminal sections around the core of the tau filament consists of over 200 amino acids, and has been characterized by NMR spectroscopy (see picture, model of the long range interactions). The results indicate how conformation specific antibodies bind to the tau protein (fibers of which are a characteristic symptom of Alzheimer disease).