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Traceless Solid‐Phase Synthesis of Trifluoromethylarenes
Author(s) -
Döbele Marion,
Wiehn Matthias S.,
Bräse Stefan
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201105446
Subject(s) - aryl , combinatorial chemistry , solid phase synthesis , halide , trifluoromethylation , linkage (software) , chemistry , cleavage (geology) , computer science , organic chemistry , materials science , peptide , biochemistry , alkyl , fracture (geology) , trifluoromethyl , composite material , gene
Save the best for last : In the first method for the trifluoromethylation of immobilized arenes, the aryl halides are attached through a dithioester linkage to the Merrifield resin and then functionalized by means of numerous reactions including transition‐metal‐catalyzed cross‐couplings. In the final step the fluorinating cleavage reaction provides the trifluoromethylarenes in good yields and high purities.