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Selective Crossed‐Tishchenko Reaction—A Waste‐Free Synthesis of Benzyl Esters
Author(s) -
Dzik Wojciech I.,
Gooßen Lukas J.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201105423
Subject(s) - carbene , atom economy , catalysis , chemistry , intermolecular force , organic chemistry , molecule
A sustainable synthesis of esters? The recent report of the selective intermolecular crossed‐Tishchenko reaction is a major advancement of this textbook reaction. In the presence of a Ni–NHC catalyst (NHC=N‐heterocyclic carbene), various benzyl esters of aliphatic acids can be synthesized with perfect atom economy from 1:1 mixtures of aromatic and aliphatic aldehydes.