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N‐Heterocyclic Carbene Catalyzed Domino Reactions
Author(s) -
Grossmann André,
Enders Dieter
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201105415
Subject(s) - domino , catalysis , carbene , cascade reaction , chemistry , combinatorial chemistry , tandem , cascade , domino effect , organic chemistry , materials science , physics , chromatography , nuclear physics , composite material
While organocatalyzed domino reactions or “organocascade catalysis” developed into an important tool in synthetic chemistry during the past decade, the utility of N‐heterocyclic carbenes (NHCs) as catalysts in domino reactions has only received growing attention in the past three years. Taking into account the unique activation modes of the substrates by NHC catalysts, it is often difficult to distinguish between a single chemical transformation and a sequential one‐pot transformation. Therefore, herein we present a critical consideration of domino, cascade, and tandem catalysis in the case of NHC catalysts and highlight recent publications in this area.