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The Conversion of Nickel‐Bound CO into an Acetyl Thioester: Organometallic Chemistry Relevant to the Acetyl Coenzyme A Synthase Active Site
Author(s) -
Horn Bettina,
Limberg Christian,
Herwig Christian,
Mebs Stefan
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201105281
Subject(s) - thioester , chemistry , yield (engineering) , cofactor , atp synthase , acetyl coa , nickel , relevance (law) , stereochemistry , combinatorial chemistry , biochemistry , organic chemistry , enzyme , political science , materials science , metallurgy , law
When three become one : Within one nickel‐based model system, the three reactants CO, MeI, and PhSH have been assembled to yield an acetyl thioester. The reactivity is of relevance for the functioning of the acetyl coenzyme A synthase active site and provides insights into possible binding sequences.