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Cobalt‐Catalyzed Coupling of Alkyl Iodides with Alkenes: Deprotonation of Hydridocobalt Enables Turnover
Author(s) -
Weiss Matthias E.,
Kreis Lukas M.,
Lauber Alex,
Carreira Erick M.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201105235
Subject(s) - alkyl , deprotonation , cobalt , catalytic cycle , catalysis , chemistry , intramolecular force , turnover number , amine gas treating , photochemistry , polymer chemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , ion
Completing the cycle : Cobalt complexes I and II were found to catalyze intramolecular alkyl Heck‐type coupling reactions of alkyl iodides to alkenes upon irradiation with visible light in the presence of a tertiary amine base. The use of base is key to the catalytic turnover. The compatibility of the method with a broad range of functional groups opens opportunities for synthesis.