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Polyvalent Immunostimulatory Nanoagents with Self‐Assembled CpG Oligonucleotide‐Conjugated Gold Nanoparticles
Author(s) -
Wei Min,
Chen Nan,
Li Jiang,
Yin Min,
Liang Le,
He Yao,
Song Haiyun,
Fan Chunhai,
Huang Qing
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201105187
Subject(s) - nanocarriers , oligonucleotide , colloidal gold , guanosine , conjugated system , conjugate , chemistry , cytosine , nanoparticle , cpg site , nanotechnology , computational biology , biochemistry , combinatorial chemistry , biophysics , biology , dna , gene , materials science , dna methylation , gene expression , organic chemistry , mathematical analysis , mathematics , polymer
Delivery vehicles : Gold nanoparticles (AuNPs) have been used as a nanocarrier to non‐invasively deliver synthetic cytosine–phosphate–guanosine (CpG) oligodeoxynucleotides (ODNs) into cells. Compared to unconjugated single‐stranded CpG ODNs, self‐assembled polyvalent CpG‐AuNP conjugates enhance the efficiency of cellular uptake and stimulate secretion of cytokines (see picture).