A Simple Enantioconvergent and Chemoenzymatic Synthesis of Optically Active α‐Substituted Amides | Zendy

Szymański Wiktor | Zendy; Westerbeek Alja | Zendy; Janssen Dick B. | Zendy; Feringa Ben L. | Zendy

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A Simple Enantioconvergent and Chemoenzymatic Synthesis of Optically Active α‐Substituted Amides

Author(s) -

Szymański Wiktor,

Westerbeek Alja,

Janssen Dick B.,

Feringa Ben L.

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201105164

Subject(s) - simple (philosophy) , yield (engineering) , enantiomer , enantiomeric excess , combinatorial chemistry , computer science , transformation (genetics) , chemistry , optically active , process (computing) , organic chemistry , enantioselective synthesis , programming language , catalysis , philosophy , materials science , biochemistry , epistemology , metallurgy , gene

Simple and efficient : The combination of an enzymatic, enantioinverting reaction with simple follow‐up processes allows the transformation of readily available racemic compounds into versatile chiral α‐substituted amides (see picture; Ms=methanesulfonyl). These important building blocks are prepared in high overall yield and enantiomeric excess; the elimination of intermediate purification steps results in a time‐ and cost‐efficient process.

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