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A Simple Enantioconvergent and Chemoenzymatic Synthesis of Optically Active α‐Substituted Amides
Author(s) -
Szymański Wiktor,
Westerbeek Alja,
Janssen Dick B.,
Feringa Ben L.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201105164
Subject(s) - simple (philosophy) , yield (engineering) , enantiomer , enantiomeric excess , combinatorial chemistry , computer science , transformation (genetics) , chemistry , optically active , process (computing) , organic chemistry , enantioselective synthesis , programming language , catalysis , philosophy , materials science , biochemistry , epistemology , metallurgy , gene
Simple and efficient : The combination of an enzymatic, enantioinverting reaction with simple follow‐up processes allows the transformation of readily available racemic compounds into versatile chiral α‐substituted amides (see picture; Ms=methanesulfonyl). These important building blocks are prepared in high overall yield and enantiomeric excess; the elimination of intermediate purification steps results in a time‐ and cost‐efficient process.