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Catalytic Gold Nanoparticles for Nanoplasmonic Detection of DNA Hybridization
Author(s) -
Zheng Xiaoxue,
Liu Qing,
Jing Chao,
Li Yang,
Li Di,
Luo Weijie,
Wen Yanqin,
He Yao,
Huang Qing,
Long YiTao,
Fan Chunhai
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201105121
Subject(s) - colloidal gold , dna , dna–dna hybridization , nanoparticle , nanotechnology , catalysis , chemistry , computational biology , biology , biophysics , biochemistry , materials science
DNA hybridization can finely regulate the intrinsic glucose oxidase like catalytic activity of AuNPs owing to the marked difference in adsorption of single‐ and double‐stranded DNA on its surface. A sensing strategy for DNA and microRNA is presented; in a different approach, this DNA‐regulated AuNP catalysis was coupled with AuNP‐mediated seed growth, which was monitored in real time and at a single‐nanoparticle level.