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Copper‐Catalyzed Oxidative CO Coupling by Direct CH Bond Activation of Formamides: Synthesis of Enol Carbamates and 2‐Carbonyl‐Substituted Phenol Carbamates
Author(s) -
Kumar G. Sathish,
Maheswari C. Uma,
Kumar R. Arun,
Kantam M. Lakshmi,
Reddy K. Rajender
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201105020
Subject(s) - formamides , chemistry , enol , formamide , catalysis , phenol , oxidative phosphorylation , oxidative coupling of methane , organic chemistry , combinatorial chemistry , medicinal chemistry , biochemistry
Formamide CH bond activation has been achieved under oxidative conditions, using a copper catalyst and tert ‐butyl hydroperoxide (TBHP) as the external oxidant (see scheme). This oxidative coupling of a range of dialkyl formamides provides an easy, phosgene‐free route for the selective synthesis of Z ‐enol carbamates and 2‐carbonyl‐substituted phenol carbamates in high yields.