Copper‐Catalyzed Oxidative CO Coupling by Direct CH Bond Activation of Formamides: Synthesis of Enol Carbamates and 2‐Carbonyl‐Substituted Phenol Carbamates | Zendy

Kumar G. Sathish | Zendy; Maheswari C. Uma | Zendy; Kumar R. Arun | Zendy; Kantam M. Lakshmi | Zendy; Reddy K. Rajender | Zendy

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Copper‐Catalyzed Oxidative CO Coupling by Direct CH Bond Activation of Formamides: Synthesis of Enol Carbamates and 2‐Carbonyl‐Substituted Phenol Carbamates

Author(s) -

Kumar G. Sathish,

Maheswari C. Uma,

Kumar R. Arun,

Kantam M. Lakshmi,

Reddy K. Rajender

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201105020

Subject(s) - formamides , chemistry , enol , formamide , catalysis , phenol , oxidative phosphorylation , oxidative coupling of methane , organic chemistry , combinatorial chemistry , medicinal chemistry , biochemistry

Formamide CH bond activation has been achieved under oxidative conditions, using a copper catalyst and tert ‐butyl hydroperoxide (TBHP) as the external oxidant (see scheme). This oxidative coupling of a range of dialkyl formamides provides an easy, phosgene‐free route for the selective synthesis of Z ‐enol carbamates and 2‐carbonyl‐substituted phenol carbamates in high yields.

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