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DNA‐Catalyzed Reductive Amination
Author(s) -
Wong On Yi,
Mulcrone Amanda E.,
Silverman Scott K.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201104976
Subject(s) - reductive amination , amination , chemistry , nucleic acid , catalysis , dna , nucleobase , combinatorial chemistry , amine gas treating , guanosine , organic chemistry , biochemistry
A new reaction for DNA : DNA is shown to catalyze Ni 2+ ‐dependent reductive amination involving the N 2 ‐amine of a guanosine nucleobase (see picture). This finding expands the repertoire of nucleic acid catalysis to include reductive amination, an important natural biosynthetic reaction that has practical synthetic utility.