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Asymmetric Hydrogenation of α‐ and β‐Enamido Phosphonates: Rhodium(I)/Monodentate Phosphoramidite Catalyst
Author(s) -
Zhang Jinzhu,
Li Yang,
Wang Zheng,
Ding Kuiling
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201104912
Subject(s) - denticity , asymmetric hydrogenation , phosphoramidite , rhodium , catalysis , ligand (biochemistry) , enantioselective synthesis , chemistry , optically active , organic chemistry , combinatorial chemistry , crystal structure , biochemistry , receptor , dna , oligonucleotide
High efficiency and enantioselectivity have been achieved in the Rh I ‐catalyzed asymmetric hydrogenation of α‐ and β‐enamido phosphonates using a monophosphoramidite as the chiral ligand (see scheme; cod=1,5‐cyclooctadiene), thus affording the optically active amino phosphonates with a turnover frequency of up to 1800 h −1 and high ee values.