Asymmetric Hydrogenation of α‐ and β‐Enamido Phosphonates: Rhodium(I)/Monodentate Phosphoramidite Catalyst | Zendy

Zhang Jinzhu | Zendy; Li Yang | Zendy; Wang Zheng | Zendy; Ding Kuiling | Zendy

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Asymmetric Hydrogenation of α‐ and β‐Enamido Phosphonates: Rhodium(I)/Monodentate Phosphoramidite Catalyst

Author(s) -

Zhang Jinzhu,

Li Yang,

Wang Zheng,

Ding Kuiling

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201104912

Subject(s) - denticity , asymmetric hydrogenation , phosphoramidite , rhodium , catalysis , ligand (biochemistry) , enantioselective synthesis , chemistry , optically active , organic chemistry , combinatorial chemistry , crystal structure , biochemistry , receptor , dna , oligonucleotide

High efficiency and enantioselectivity have been achieved in the Rh I ‐catalyzed asymmetric hydrogenation of α‐ and β‐enamido phosphonates using a monophosphoramidite as the chiral ligand (see scheme; cod=1,5‐cyclooctadiene), thus affording the optically active amino phosphonates with a turnover frequency of up to 1800 h −1 and high ee values.

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