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Three‐Component Coupling of Arynes and Organic Bromides
Author(s) -
Yoshida Hiroto,
Asatsu Yuji,
Mimura Yasuhiro,
Ito Yu,
Ohshita Joji,
Takaki Ken
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201104858
Subject(s) - aryne , nucleophile , magic (telescope) , component (thermodynamics) , bromine , computer science , chemistry , combinatorial chemistry , organic chemistry , physics , quantum mechanics , thermodynamics , catalysis
Magic trio : Arynes are easily coupled with neutral nucleophiles and organic bromides to afford functionalized bromoarenes depending upon the nucleophile (Nu). The three‐component coupling proceeds through the formation of bromine ate complexes, and can be applied to the synthesis of multisubstituted isoquinolines and benzo[ b ]oxepines having pharmacological activity.