Premium
A Versatile Synthesis of Substituted Isoquinolines
Author(s) -
Si Chong,
Myers Andrew G.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201104769
Subject(s) - electrophile , diversification (marketing strategy) , computer science , work (physics) , combinatorial chemistry , information retrieval , chemistry , organic chemistry , business , engineering , mechanical engineering , marketing , catalysis
Lithiated o ‐tolualdehyde tert ‐butylimines were shown to condense with nitriles to form eneamido anion intermediates that were trapped in situ with various electrophiles, thus affording a diverse array of highly substituted isoquinolines, many of which are difficult to access by known methods. Further substitutional diversification was achieved by modification of the work‐up conditions and by subsequent transformations.