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Mannose‐Functionalized Mesoporous Silica Nanoparticles for Efficient Two‐Photon Photodynamic Therapy of Solid Tumors
Author(s) -
GaryBobo Magali,
Mir Youssef,
Rouxel Cédric,
Brevet David,
Basile Ilaria,
Maynadier Marie,
Vaillant Ophélie,
Mongin Olivier,
BlanchardDesce Mireille,
Morère Alain,
Garcia Marcel,
Durand JeanOlivier,
Raehm Laurence
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201104765
Subject(s) - photodynamic therapy , nanoparticle , in vivo , mesoporous silica , two photon excitation microscopy , mesoporous material , photon , nanotechnology , excitation , materials science , chemistry , computer science , cancer research , medicine , optics , biochemistry , physics , organic chemistry , biology , microbiology and biotechnology , catalysis , quantum mechanics
Zap 'em! Multifunctionalized mesoporous silica nanoparticles induce significant reduction of tumor size upon two‐photon excitation in the near‐infrared region while being nontoxic under daylight illumination. These nanoparticles were further tested for in vivo two‐photon photodynamic therapy (TPE‐PDT). A 70 % regression of tumor size after a single treatment was observed in athymic mice bearing tumor xenografts.