Amination of Benzoxazoles and 1,3,4‐Oxadiazoles Using 2,2,6,6‐Tetramethylpiperidine‐ N ‐oxoammonium Tetrafluoroborate as an Organic Oxidant | Zendy

Wertz Sebastian | Zendy; Kodama Shintaro | Zendy; Studer Armido | Zendy

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Amination of Benzoxazoles and 1,3,4‐Oxadiazoles Using 2,2,6,6‐Tetramethylpiperidine‐ N ‐oxoammonium Tetrafluoroborate as an Organic Oxidant

Author(s) -

Wertz Sebastian,

Kodama Shintaro,

Studer Armido

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201104735

Subject(s) - tetrafluoroborate , amination , chemistry , organic chemistry , medicinal chemistry , combinatorial chemistry , ionic liquid , catalysis

No transition metals are necessary to convert benzoxazoles and 1,3,4‐oxadiazoles into the corresponding pharmacologically interesting 2‐aminated heterocycles by formal direct C(2)‐amination using tetramethylpiperidine‐ N ‐oxoammonium tetrafluoroborate (TEMPO + BF 4 − ) as an oxidant (see scheme; TEMP=2,2,6,6‐tetramethylpiperidine; TfOH=trifluoromethanesulfonic acid).

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