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Convenient and General Palladium‐Catalyzed Carbonylative Sonogashira Coupling of Aryl Amines
Author(s) -
Wu XiaoFeng,
Neumann Helfried,
Beller Matthias
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201104653
Subject(s) - sonogashira coupling , phosphine , aryl , palladium , chemistry , catalysis , carbonylation , combinatorial chemistry , organic chemistry , medicinal chemistry , carbon monoxide , alkyl
Bar (alky)none: A general and efficient method for carbonylative Sonogashira coupling reactions of anilines to generate alkynones has been developed (see scheme; TFP=tri(2‐furyl)phosphine). The reaction proceeds under mild conditions and no base is needed.
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