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Accelerating Palladium‐Catalyzed CF Bond Formation: Use of a Microflow Packed‐Bed Reactor
Author(s) -
Noël Timothy,
Maimone Thomas J.,
Buchwald Stephen L.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201104652
Subject(s) - microreactor , palladium , aryl , catalysis , packed bed , mixing (physics) , chemistry , combinatorial chemistry , organic chemistry , physics , chromatography , alkyl , quantum mechanics
A flow process for Pd‐catalyzed CF bond formation is described. A microreactor with a packed‐bed design allows for easy handling of large quantities of insoluble CsF with precise control over reaction times, efficient mixing, and the ability to safely handle elevated temperatures and pressures. A variety of aryl triflates, including heteroaryl ones, were converted into aryl fluorides in short reaction times (see scheme).