Premium
Synthetic Antitumor Vaccines Containing MUC1 Glycopeptides with Two Immunodominant Domains—Induction of a Strong Immune Response against Breast Tumor Tissues
Author(s) -
Gaidzik Nikola,
Kaiser Anton,
Kowalczyk Danuta,
Westerlind Ulrika,
Gerlitzki Bastian,
Sinn Hans Peter,
Schmitt Edgar,
Kunz Horst
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201104529
Subject(s) - glycopeptide , muc1 , immune system , breast tumor , medicine , immunology , cancer research , biology , breast cancer , antigen , microbiology and biotechnology , cancer , antibiotics
A shot in the arm for cancer treatment : Two MUC1 tetanus toxoid vaccines were synthesized and induced a strong immune response in mice. The antibodies elicited by the vaccines show a high selectivity for the tumor cells in mammary carcinoma tissues and also distinguish between tumor tissues at different stages.