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Cover Picture: Total Synthesis of (+)‐Omphadiol (Angew. Chem. Int. Ed. 33/2011)
Author(s) -
Liu Gang,
Romo Daniel
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201104527
Subject(s) - total synthesis , bicyclic molecule , cover (algebra) , lactone , int , stereochemistry , chemistry , computer science , engineering , operating system , mechanical engineering
A high ratio of CC bond‐forming steps and a high degree of stereocontrol characterizes the first total synthesis of (+)‐omphadiol. In their Communication on page 7537 ff., D. Romo and G. Lui report a facile conversion of ( R )‐carvone, from the spearmint plant, into omphadiol, from the jack‐o'‐lantern mushroom, via a versatile bicyclic β‐lactone. Several one‐pot or sequential processes and the absence of protecting groups contribute to the brevity of the synthesis.