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Cover Picture: Total Synthesis of Synechoxanthin through Iterative Cross‐Coupling (Angew. Chem. Int. Ed. 34/2011)
Author(s) -
Fujii Seiko,
Chang Stephanie Y.,
Burke Martin D.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201104526
Subject(s) - nucleophile , electrophile , total synthesis , cover (algebra) , coupling (piping) , iterative method , simple (philosophy) , computer science , coupling reaction , chemistry , algorithm , combinatorial chemistry , stereochemistry , materials science , engineering , organic chemistry , philosophy , mechanical engineering , epistemology , catalysis , metallurgy
Iterative cross‐coupling of preassembled building blocks is a simple strategy for the construction of complex small molecules. M. D. Burke and co‐workers describe in their Communication on page 7862 ff. the efficient transformation of a boronate functional group into either a nucleophile or an electrophile. This advance enabled the total synthesis of synechoxanthin by assembling three building blocks iteratively with only one reaction.