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Oligonucleotide Delivery by Cell‐Penetrating “Striped” Nanoparticles
Author(s) -
Jewell Christopher M.,
Jung JinMi,
Atukorale Prabhani U.,
Carney Randy P.,
Stellacci Francesco,
Irvine Darrell J.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201104514
Subject(s) - endocytosis , oligonucleotide , dna , nanoparticle , ligand (biochemistry) , colloidal gold , conjugated system , biophysics , nanotechnology , homogeneous , nanomedicine , cell , chemistry , microbiology and biotechnology , materials science , biology , receptor , biochemistry , physics , polymer , thermodynamics , organic chemistry
Gold nanoparticles coated with homogeneous (MUS) or “striped” (MUS‐OT) ligand shells can be conjugated with double or single stranded DNA, and particles with either ligand configuration effectively carry DNA into melanoma tumor cells. When endocytosis is inhibited, however, MUS‐OT particles continue to mediate DNA delivery, while the delivery ability of MUS particles is abolished.