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X‐Ray Computed Tomography Imaging of Breast Cancer by using Targeted Peptide‐Labeled Bismuth Sulfide Nanoparticles
Author(s) -
Kinsella Joseph M.,
Jimenez Rebecca E.,
Karmali Priya P.,
Rush Anthony M.,
Kotamraju V. Ramana,
Gianneschi Nathan C.,
Ruoslahti Erkki,
Stupack Dwayne,
Sailor Michael J.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201104507
Subject(s) - nanoparticle , peptide , computed tomography , breast cancer , bismuth , cancer imaging , computed tomography laser mammography , tomography , cancer , x ray , materials science , sulfide , chemistry , nuclear medicine , nanotechnology , preclinical imaging , medicine , radiology , optics , biochemistry , in vivo , organic chemistry , physics , microbiology and biotechnology , biology
Enhanced visualization of breast cancer in X‐ray computed tomography was achieved by using Bi 2 S 3 nanoparticles of 10 nm diameter modified to display a tumor targeting peptide (LyP‐1, CGNKRTRGC). Accumulation within the tumor was increased by 260 % over non‐labeled nanoparticles.