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A Highly Efficient and Enantioselective Access to Tetrahydroisoquinoline Alkaloids: Asymmetric Hydrogenation with an Iridium Catalyst
Author(s) -
Chang Mingxin,
Li Wei,
Zhang Xumu
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201104476
Subject(s) - enantioselective synthesis , iridium , tetrahydroisoquinoline , enantiomer , combinatorial chemistry , catalysis , chemistry , computer science , stereochemistry , organic chemistry
Efficient and enantioselective : Using the iodine‐bridged dimeric iridium complex [{Ir(H)[( S , S )‐(f)‐binaphane]} 2 (μ‐I) 3 ] + I − ( 1 ) a wide range of tetrahydroisoquinoline alkaloids, including the substructure of the pharmaceutical drug solifenacin, were obtained with excellent enantioselectivities and high turnover numbers (see scheme).