Premium
Formation of Sequence‐Independent Z‐DNA Induced by a Ruthenium Complex at Low Salt Concentrations
Author(s) -
Wu Zhiguo,
Tian Tian,
Yu Junping,
Weng Xiaocheng,
Liu Yi,
Zhou Xiang
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201104422
Subject(s) - isothermal titration calorimetry , ruthenium , dna , salt (chemistry) , phenanthroline , sequence (biology) , aqueous solution , chemistry , titration , calorimetry , crystallography , stereochemistry , inorganic chemistry , biochemistry , physics , thermodynamics , catalysis
Switched : The metal complex [Ru(dip) 2 dppz] 2+ can induce the transition from B‐DNA to Z‐DNA and stabilize the Z conformation in aqueous low‐salt solution (see scheme; dip=4,7‐diphenyl‐1,10‐phenanthroline, dppz=dipyridophenazine). The transition is sequence‐independent (including non‐alternating pyrimidine–purine and AT‐rich sequences) and was monitored by CD and 2D NMR spectroscopy, AFM, isothermal titration calorimetry, and gel electrophoresis.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom