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Bioorthogonal Reaction Pairs Enable Simultaneous, Selective, Multi‐Target Imaging
Author(s) -
Karver Mark R.,
Weissleder Ralph,
Hilderbrand Scott A.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201104389
Subject(s) - bioorthogonal chemistry , tetrazine , cycloaddition , computer science , chemistry , combinatorial chemistry , azide , reactivity (psychology) , information retrieval , click chemistry , biochemistry , organic chemistry , medicine , alternative medicine , pathology , catalysis
Mutually orthogonal tetrazine–trans‐cyclooctene and azide–cyclooctyne cycloaddition reactions were used simultaneously for the bioorthogonal labeling of two different live cell populations in the same culture (see scheme). These small‐molecule probes show good chemical reactivity and can be readily incorporated into biological systems.