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Exploring the Piezophilic Behavior of Natural Cosolvent Mixtures
Author(s) -
Schroer Martin A.,
Zhai Yong,
Wieland D. C. Florian,
Sahle Christoph J.,
Nase Julia,
Paulus Michael,
Tolan Metin,
Winter Roland
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201104380
Subject(s) - urea , intermolecular force , chemistry , lysozyme , mechanism (biology) , content (measure theory) , food science , biochemistry , organic chemistry , philosophy , epistemology , mathematics , molecule , mathematical analysis
Marine organisms have evolved a surprising mechanism to counteract the deleterious effects of urea by trimethylammonium N ‐oxide (TMAO). The effect of pressure on the structure and intermolecular interactions of lysozyme in urea and TMAO solutions was studied (see picture). These findings help to understand the compensatory effect of urea–TMAO mixtures in deep‐sea organisms.