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A Single Phosphine Ligand Allows Palladium‐Catalyzed Intermolecular CO Bond Formation with Secondary and Primary Alcohols
Author(s) -
Wu Xiaoxing,
Fors Brett P.,
Buchwald Stephen L.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201104361
Subject(s) - palladium , aryl , halide , chemistry , phosphine , ligand (biochemistry) , catalysis , aryl halide , primary (astronomy) , combinatorial chemistry , organic chemistry , alkyl , receptor , physics , astronomy , biochemistry
Forging a bond : An efficient, general palladium catalyst for CO bond‐forming reactions of secondary and primary alcohols with a range of aryl halides has been developed using the ligand 1 . Heteroaryl halides, and for the first time, electron‐rich aryl halides can be coupled with secondary alcohols. A diverse set of substrate combinations are possible with just a single ligand, thus obviating the need to survey multiple ligands.