A Single Phosphine Ligand Allows Palladium‐Catalyzed Intermolecular CO Bond Formation with Secondary and Primary Alcohols | Zendy

Wu Xiaoxing | Zendy; Fors Brett P. | Zendy; Buchwald Stephen L. | Zendy

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A Single Phosphine Ligand Allows Palladium‐Catalyzed Intermolecular CO Bond Formation with Secondary and Primary Alcohols

Author(s) -

Wu Xiaoxing,

Fors Brett P.,

Buchwald Stephen L.

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201104361

Subject(s) - palladium , aryl , halide , chemistry , phosphine , ligand (biochemistry) , catalysis , aryl halide , primary (astronomy) , combinatorial chemistry , organic chemistry , alkyl , receptor , physics , astronomy , biochemistry

Forging a bond : An efficient, general palladium catalyst for CO bond‐forming reactions of secondary and primary alcohols with a range of aryl halides has been developed using the ligand 1 . Heteroaryl halides, and for the first time, electron‐rich aryl halides can be coupled with secondary alcohols. A diverse set of substrate combinations are possible with just a single ligand, thus obviating the need to survey multiple ligands.

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